Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats

The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

Amy S. Lee · Methods · 2005 · 994 citations

Life Sciences, Cell Biology, Molecular Biology +16

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

Inge A.M. de Graaf, Peter Olinga, Marina H. de Jager et al. · Nature Protocols · 2010 · 408 citations · Full text

Pharmacy, Pharmacology, Toxicology +10

Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID induced injury to the rat intestine

Siva G. Somasundaram, S Rafi, Jeremy Hayllar et al. · Gut · 1997 · 317 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID‐enteropathy in the rat

Siva G. Somasundaram, Sigthorsson, Robert J. Simpson et al. · Alimentary Pharmacology & Therapeutics · 2000 · 264 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis

Shinji Tsutsumi, Tomomi Gotoh, Wataru Tomisato et al. · Cell Death and Differentiation · 2004 · 253 citations

Life Sciences, Cell Biology, Pharmacology +14