Follistatin‐like protein 1 is a mesenchyme‐derived inflammatory protein and may represent a biomarker for systemic‐onset juvenile rheumatoid arthritis

Abstract

These findings demonstrate that the arthritic joint matrix is a major source of FSTL-1 and that IL-1beta is a central mediator of FSTL-1 secretion. Furthermore, FSTL-1 may represent a useful biomarker of disease activity in systemic-onset JRA.