Hepatitis B Virus Mutants with Precore-Region Defects in Two Babies with Fulminant Hepatitis and Their Mothers Positive for Antibody to Hepatitis B e Antigen

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

RK Saiki, DH Gelfand, Susanne Stoffel et al. · Science · 1988 · 4.3K citations

Life Sciences, Biotechnology, Molecular Biology +12

E Antigen and Anti-E in the Serum of Asymptomatic Carrier Mothers as Indicators of Positive and Negative Transmission of Hepatitis B Virus to Their Infants

Kiyshi Okada, Ichiro Kamiyama, Minako Inomata et al. · New England Journal of Medicine · 1976 · 730 citations

Medicine, Infectious Diseases, Maternal Health +14

Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen

Hiroaki Okamoto, S Yotsumoto, Y. Akahane et al. · Journal of Virology · 1990 · 518 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +16

Detection of Hepatitis B Virus DNA in Serum by a Simple Spot Hybridization Technique: Comparison with Results for Other Viral Markers

J Scotto, Michelle Hadchouel, Christiane Héry et al. · Hepatology · 1983 · 474 citations

Life Sciences, Infectious Diseases, Molecular Biology +14