Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: Comparative study of four distinct genotypes

Hiroaki Okamoto, Kiyohiko Kurai, Shunichi Okada, +6

Virology

Distinct GenotypesHepatitis CViral HepatitisGeneticsFull-length Sequence +11

Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen

Hiroaki Okamoto, S Yotsumoto, Y. Akahane, +7

Journal of Virology

VaccinationViral ReplicationMolecular VirologyViral PersistenceC Gene +13

Infection with Hepatitis GB Virus C in Patients on Maintenance Hemodialysis

Kazuo Masuko, Takehiro Mitsui, Keiko Iwano, +9

New England Journal of Medicine

Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen

Kayoko Yamamoto, Minoru Horikita, Fumio Tsuda, +6

Journal of Virology

Escape MutantsViral ReplicationMolecular VirologyPoint MutationsViral Hepatitis +12

Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product

Sadakazu Usuda, Hiroaki Okamoto, Hiroko Iwanari, +4

Journal of Virological Methods

VaccinationDiagnostic VirologySerological DetectionViral DiagnosticsViral Hepatitis +10

Fulminant hepatitis B: Induction by hepatitis B virus mutants defective in the precore region and incapable of encoding E antigen

Yoshitane Kosaka, Kohjiro Takase, Mineo Kojima, +9

Gastroenterology

Fulminant Hepatitis BPrecore RegionHepatologyViral HepatitisPathogenesis +8

A synthetic peptide vaccine involving the product of the pre-S(2) region of hepatitis B virus DNA: protective efficacy in chimpanzees.

Yoshito Itoh, Emiko Takai, Hiroyuki Ohnuma, +7

Proceedings of the National Academy of Sciences

VaccinationProtective EfficacyVaccine DevelopmentViral HepatitisVaccine Target +12

Swine hepatitis E virus strains in Japan form four phylogenetic clusters comparable with those of Japanese isolates of human hepatitis E virus

Masaharu Takahashi, Tsutomu Nishizawa, Haruko Miyajima, +4

Journal of General Virology

Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr

Hiroaki Okamoto, Masayuki Imai, Fumio Tsuda, +3

Journal of Virology

Viral ReplicationGeneticsGenetic EpidemiologyHepatitis BImmunology +14

Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan

Hitoshi Mizuo, Yasuyuki Yazaki, Kenji Sugawara, +4

Journal of Medical Virology

Hepatitis BIndustrialized CountriesCirrhosisViral HepatitisHepatotoxicity +15