Rise and fall of minocycline in neuroprotection: need to promote publication of negative results

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Du Chu Wu, Vernice Jackson‐Lewis, Miquel Vila et al. · Journal of Neuroscience · 2002 · 1.2K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

Shan Zhu, Irina G. Stavrovskaya, Martin Drozda et al. · Nature · 2002 · 1.1K citations

Life Sciences, Neurology, Neuroscience +14

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

Minghua Chen, Victor Ona, Mingwei Li et al. · Nature Medicine · 2000 · 1.1K citations

Life Sciences, Neurology, Neuroscience +17

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

Juha Yrjänheikki, Tiina Tikka, Riitta Keinänen et al. · Proceedings of the National Academy of Sciences · 1999 · 1K citations

Life Sciences, Neuroscience, Pharmacology +17

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Juha Yrjänheikki, Riitta Keinänen, M. Pellikka et al. · Proceedings of the National Academy of Sciences · 1998 · 996 citations

Medicine, Pharmacology, Molecular Neurobiology +12