An Entropically Efficient Supramolecular Inhibition Strategy for Shiga Toxins

Abstract

A compact heterobifunctional ligand devoid of a linker between binding functionalities induces a supramolecular assembly between two pentameric proteins, Shiga toxin (blue) and serum amyloid P component, a human serum protein (turquoise). The use of an endogenous protein as a template brings about a 10 000-fold enhancement of ligand activity.