A new synthesis of (+)-6a-carbaprostaglandin I2 employing yeast reduction of a β-keto ester derived from -bicyclo[3.3.0] octane-3,7-dione as the key-step

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters

James A. Dale, Harry S. Mosher · Journal of the American Chemical Society · 1973 · 2.6K citations

Natural Sciences, Chemistry, Nuclear Chemistry +6

The Utility of Phosphonate Carbanions in Olefin Synthesis

William S. Wadsworth, William D. Emmons · Journal of the American Chemical Society · 1961 · 1.4K citations

Natural Sciences, Chemistry, Analytical Chemistry +4

Asymmetric reductinon of carbonyl compounds by yeast. II. Preparation of optically active α- and β-hydroxy carboxylic acid derivatives

BS Deol, DD Ridley, GW Simpson · Australian Journal of Chemistry · 1976 · 185 citations

Natural Sciences, Biochemistry, Chemistry +14

Carbacyclin — A potent stable prost acyclin analogue for the inhibition of platelet aggregation

B.J.R. Whittle, Salvador Moncada, F. Whiting et al. · Prostaglandins · 1980 · 121 citations

Medicine, Medicinal Chemistry, Pharmacology +14