Association of Granulomatosis With Polyangiitis (Wegener's) With <i>HLA–DPB1*04</i> and <i>SEMA6A</i> Gene Variants: Evidence From Genome‐Wide Analysis

Abstract

We identified the SEMA6A and HLA-DP loci as significant contributors to risk for GPA, with the HLA-DPB1*04 allele almost completely accounting for the MHC association. These two associations confirm the critical role of immunogenetic factors in the development of GPA.