Concepedia

A potential mechanism of metformin-mediated regulation of glucose homeostasis: Inhibition of Thioredoxin-interacting protein (Txnip) gene expression

Tin Fan Chai, Shin Yee Hong, Hongpeng He, Liling Zheng, Thilo Hagen, Yan Luo, Fa‐Xing Yu

Cellular Signalling · 2012 · 51 citations · 32 references

DOI

Concepts

References

32

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.4K citations

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

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Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I

Mohamad-Yehia El-Mir, Véronique Nogueira, Éric Fontaine et al. · Journal of Biological Chemistry · 2000 · 1.4K citations · Full text

, , +17

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

Marc Foretz, Sophie Hébrard, Jocelyne Leclerc et al. · Journal of Clinical Investigation · 2010 · 1.2K citations · Full text

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Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

Adem Kalender, Anand Selvaraj, So Young Kim et al. · Cell Metabolism · 2010 · 874 citations · Full text

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