Cytotoxicity of cisplatin in bladder cancer is significantly enhanced by application of bcl-2 antisense oligonucleotides

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

Y Tsujimoto, Carlo M. Croce · Proceedings of the National Academy of Sciences · 1986 · 1.1K citations · Full text

Amino Acids, Mixed-phenotype Acute Leukemia, Genetics +18

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

Toshiyuki Miyashita, JC Reed · Blood · 1993 · 876 citations · Full text

Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

Annemarie Ziegler, G. H. Luedke, Rolf A. Stahel et al. · JNCI Journal of the National Cancer Institute · 1997 · 219 citations · Full text

Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance.

Charles M. Rudin, Zejia Yang, Lisa M. Schumaker et al. · PubMed · 2003 · 174 citations

Reductive Stress, Molecular Pharmacology, Tumor Biology +14

Overexpression of Bcl-2 in bladder cancer cells inhibits apoptosis induced by cisplatin and adenoviral-mediated p53 gene transfer

Hideaki Miyake, Norihisa Hanada, Hideo Nakamura et al. · Oncogene · 1998 · 121 citations

Tumor Biology, Urology, Genitourinary Cancer +10