Concepedia

Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

Annemarie Ziegler, G. H. Luedke, Rolf A. Stahel, Uwe Zangemeister‐Wittke, Doriano Fabbro, Katrin Altmann

JNCI Journal of the National Cancer Institute · 1997 · 219 citations · 38 references

DOIFull text

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Abstract

We have identified a novel antisense ODN sequence (ODN 2009) that effectively reduces the viability of small-cell lung cancer cells by reducing Bcl-2 levels and facilitating apoptosis.

References

38

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.2K citations

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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Piotr Chomczyński, Nicoletta Sacchi · Analytical Biochemistry · 1987 · 46.8K citations

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Cancer: Principles and Practice of Oncology.

Annals of Internal Medicine · 1991 · 8.5K citations

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

Ildo Nicoletti, Graziella Migliorati, Maria Cristina Pagliacci et al. · Journal of Immunological Methods · 1991 · 4.6K citations

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

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