A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

Medicine, Cancer Biology, Molecular Genetics +14

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

Medicine, Oncology, Pharmacology +15

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Scott W. Lowe, H. Earl Ruley, Tyler Jacks et al. · Cell · 1993 · 2.9K citations

Life Sciences, Cancer Biology, Oncology +14

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Jerry E. Chipuk, Tomomi Kuwana, Lisa Bouchier‐Hayes et al. · Science · 2004 · 2K citations

Life Sciences, Cell Biology, Oncology +15

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

Roberto Montes de Oca Luna, Daniel S. Wagner, Guillermina Lozano · Nature · 1995 · 1.4K citations

Life Sciences, Genetics, Molecular Biology +12