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A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors

BiochemistryProtein FoldingNatural SciencesUnmodified Nucleotide InhibitorsEnzyme CatalysisOligonucleotideMolecular BiologyConformational StudyConformational TransitionStructure-function Enzyme KineticsMedicineStructural Biology