Concepedia

Dietary Fiber Enhances a Tumor Suppressor Signaling Pathway in the Gut

Khoa A. Nguyen, Yanna Cao, Justin R. Chen, Courtney M. Townsend, Tien C. Ko

Annals of Surgery · 2006 · 44 citations · 33 references

DOIFull text

Open access

Abstract

These results demonstrate that NaB induces Smad3 and potentiates TGF-beta signaling and its tumor suppressor activity in gut epithelial cells. Our data reveal a novel molecular mechanism that may explain in part the beneficial effects of dietary fiber in decreasing the risk of colon cancers.

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