Molecular modeling of novel 1H-pyrazolo[3,4-b]pyridine derivatives designed as isosters of the antimalarial mefloquine

Stereochemistry of cooperative mechanisms in hemoglobin

M. F. Perutz, G. Fermi, Ben F. Luisi et al. · Accounts of Chemical Research · 1987 · 419 citations

Natural Sciences, Biochemistry, Chemistry +13

Identification of the acidic compartment of Plasmodium falciparum‐infected human erythrocytes as the target of the antimalarial drug chloroquine.

Avner Yayon, Z. Ioav Cabantchik, H. Ginsburg · The EMBO Journal · 1984 · 310 citations · Full text

Medicine, Infectious Diseases, Pharmacology +12

Molecular Cloning of Human GDP-mannose 4,6-Dehydratase and Reconstitution of GDP-fucose Biosynthesis in Vitro

Francis X. Sullivan, Ravindra Kumar, Ronald Kriz et al. · Journal of Biological Chemistry · 1998 · 166 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Antimalarials. 7. Bis(trifluoromethyl)-.alpha.-(2-piperidyl)-4-quinolinemethanols

Robert E. Lutz, C.J. Ohnmacht, A. R. Patel · Journal of Medicinal Chemistry · 1971 · 154 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance

J. A. Simpson, Emmeline R. Watkins, Ric N. Price et al. · Antimicrobial Agents and Chemotherapy · 2000 · 119 citations

Medicine, Infectious Diseases, Pharmacology +17