The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease

Molecular cloning: A laboratory manual

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Molecular Biotechnology, Natural Sciences, Genetics +8

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.2K citations

Nucleic Acid Chemistry, Engineering, Natural Sciences +7

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

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Transcriptional Regulation, Signal Transduction, Nuclear Factor Creb +5

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

Christopher D. Reiter, Xunde Wang, José E. Tanus‐Santos et al. · Nature Medicine · 2002 · 1.1K citations

Sickle-cell Disease, Immunology, Hematology +4