Physicochemical Characterization and Membrane Binding Properties of Camptothecin

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Microviscosity and order in the hydrocarbon region of micelles and membranes determined with fluorescent probes. I. Synthetic micelles

Gregorio Weber, Meir Shinitzky, Anne Christine Dianoux et al. · Biochemistry · 1971 · 555 citations

Natural Sciences, Biochemistry, Biophysics +16

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

William D. Kingsbury, Jeffrey C. Boehm, Dalia R. Jakas et al. · Journal of Medicinal Chemistry · 1991 · 516 citations

Medicine, Medicinal Chemistry, Pharmacology +10

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Julianne Fassberg, Valentino J. Stella · Journal of Pharmaceutical Sciences · 1992 · 464 citations

Life Sciences, Biochemistry, Chemistry +12

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

Christine Jaxel, Kurt W. Kohn, Mansukh C. Wani et al. · PubMed · 1989 · 450 citations

Medicine, Medicinal Chemistry, Pharmacology +14