Concepedia

Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer

Yutaka Yamamoto, Mutsuko Ibusuki, Yasuhiro Okumura, Teru Kawasoe, Kazuharu Kai, Ken‐ichi Iyama, Hirotaka Iwase

Breast Cancer Research and Treatment · 2007 · 149 citations · 42 references

DOI

Concepts

References

42

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up

C.W. Elston, Ian O. Ellis · Histopathology · 1991 · 6.2K citations

, , +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

, , +14

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

Jo A. Forsythe, Bing‐Hua Jiang, Narayan V. Iyer et al. · Molecular and Cellular Biology · 1996 · 4K citations · Full text

, , +15

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

Peter Vaupel, F. Kallinowski, Paul Okunieff · PubMed · 1989 · 3.4K citations

, , +16