1c:I[419806,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 1d:T499,Neonatally thymectomized mice were implanted intraperitoneally at 7 days of age with Millipore diffusion chambers containing either embryonic or neonatal thymus tissue. Mice which received either empty diffusion chambers or no further treatment following neonatal thymectomy served as controls. In contrast to these controls, most of the mice implanted with thymus-filled chambers gained weight satisfactorily, did not develop a wasting syndrome, and had the capacity to produce serum antibodies in response to sheep erythrocytes and to reject allogeneic skin grafts. Lymphoid follicles were present in the lymph nodes, spleen, and intestinal tract of the implanted mice but most still showed some diminution in the population of lymphocytes in both blood and tissues. Control thymectomized mice had markedly depleted lymphoid tissues and low peripheral blood lymphocyte levels. The tissue recovered after 1 to 2 months from the diffusion chambers showed only epithelial-reticular cells but no lymphoid cells. It is suggested that a humoral factor produced by the thymus epithelial-reticular complex may be responsible for endowing lymphoid cells with immunological competence.1e:T414,It has been known for a long time that there is an association of some sort between thymic lesions, thymomas in particular, and myasthenia gravis.¹More recently, cross-reactions have been demonstrated between antimuscle antibodies in the sera of individuals suffering from myasthenia gravis and certain cells of the thymus.^2,3There is little doubt that the reactive elements in the thymus are not entodermal reticular elements, but actual muscle cells, the "myoidzellen" of the old anatomists.⁴ Elongated, occasionally stellate, eosinophilic cells containing cross-striated fibrils have been reported among thymocytes and reticular cells of the thymus in a variety of vertebrates. First described by Mayer⁵in the frog's thymus, they were observed by him as long, spindle-shaped elements showing distinct striations and closely resembling rudimentary skeletal muscle fibers. Pensa⁶found these strange cells to be particularly numerous and well developed in the thymus of chickens and called1f:T579,

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