A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

Donald A. McClain, Hiroshi Maegawa, J Lee et al. · Journal of Biological Chemistry · 1987 · 405 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

J F, Madhur K. Sinha, S Raju et al. · Journal of Clinical Investigation · 1987 · 343 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Thiazolidinediones in the treatment of insulin resistance and type II diabetes

A. R. Saltiel, Jerrold M. Olefsky · Diabetes · 1996 · 303 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and Type 2 (non-insulin-dependent) diabetes mellitus

Peter Arner, Thomas Pollare, Hans Lithell et al. · Diabetologia · 1987 · 179 citations · Full text

Medicine, Endocrinology, Molecular Biology +14

A defective Intramolecular Autoactivation Cascade May Cause the Reduced Kinase Activity of the Skeletal Muscle Insulin Receptor from Patients with Non-insulin-dependent Diabetes Mellitus

B. Obermaier–Kusser, Morris F. White, D. Pongratz et al. · Journal of Biological Chemistry · 1989 · 109 citations · Full text

Life Sciences, Endocrinology, Physiology +14