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Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series

Medicinal ChemistryPharmaceutical ScienceHydroxyl GroupBiochemistryMedicineNatural SciencesPyrazine Carboxamide Cb1Pharmaceutical PropertiesRational Drug DesignPharmacological AgentPharmacotherapyDrug DevelopmentPharmacologyPharmaceutical ChemistryDrug Discovery