Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed · 1997 · 66.5K citations

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Knockout Mouse, Mendelian Disorder, Aging +8

Identification of the HumanKlothoGene and Its Two Transcripts Encoding Membrane and SecretedKlothoProtein

Yutaka Matsumura, Hiroki Aizawa, Takako Shiraki-Iida et al. · Biochemical and Biophysical Research Communications · 1998 · 680 citations

Chromatin, Signal Transduction, Biochemistry +7

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains

Suresh Cuddapah, Raja Jothi, Dustin E. Schones et al. · Genome Research · 2008 · 640 citations · Full text

Epigenetic Change, Molecular Biology, Chromatin Barrier Regions +18

Large-Scale in Silico and Microarray-Based Identification of Direct 1,25-Dihydroxyvitamin D3 Target Genes

Tiantian Wang, Luz E. Tavera-Mendoza, David Laperrière et al. · Molecular Endocrinology · 2005 · 575 citations · Full text

Engineering, Genetics, Conserved Vdres +22