Hereditary Nonpolyposis Colorectal Cancer Families Not Complying with the Amsterdam Criteria Show Extremely Low Frequency of Mismatch-Repair-Gene Mutations

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

Richard Fishel, Mary Kay Lescoe, Manchanahalli R. Satyanarayana Rao et al. · Cell · 1993 · 2.9K citations

Life Sciences, Genetics, Oncology +14

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

Yurij Ionov, Miguel A. Peinado, Sergei Malkhosyan et al. · Nature · 1993 · 2.7K citations

Medicine, Genetics, Molecular Genetics +17

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Fredrick S. Leach, Nicholas C. Nicolaides, Nickolas Papadopoulos et al. · Cell · 1993 · 2.3K citations

Life Sciences, Genetics, Molecular Genetics +17

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

Hans F. A. Vasen, Jukka‐Pekka Mecklin, P. Meera Khan et al. · Diseases of the Colon & Rectum · 1991 · 2.2K citations

Medicine, Genetics, Oncology +17