Synthese von Glycerylätherphosphatiden 2. Mitteilung Herstellung von 2‐<i>O</i>‐Acetyl‐1‐<i>O</i>‐[(<i>Z</i>)‐9‐octadecenyl] ‐<i>sn</i>‐glyceryl‐3‐phosphorylcholin («Oleyl‐PAF»), des Enantiomeren sowie einiger analoger, ungesättigter Verbindungen

Abstract

Synthesis of Glyceryletherphosphatides, 2nd Communication. Preparation of 2‐ O ‐Acetyl‐1‐ O ‐[( Z )‐9‐octadecenyl]‐ sn ‐glyceryl‐3‐phosphorylcholin (‘Oleyl‐PAF’), of its Enantiomer and Some Analogous, Unsaturated Compounds Syntheses of the unsaturated glyceroletherphospholipid 1a as an olefin‐analog of ‘ Platelet Activating Factor ’ (PAF) are described together with the methods for the preparation of the enantiomer 1′a , the corresponding ‘ lyso compounds ’ 1b and 1′b and their positional isomers 21a, 21′a, 26, 26′, 25, 25′ obtained on formally exchanging the attachment site of the functional groups at the glycerol moiety. Structural assignments and optical purity of the compounds are confirmed.