Synthesis, structure and investigations of tuberculosis inhibition activities of new 4‐methyl‐1‐substituted‐1<i>H</i>‐1,2,4‐triazole‐5(4<i>H</i>)‐thione

Abstract

Abstract magnified image By the reaction aminomethylation, chloromethylation and acylation of 4‐methyl‐4 H ‐1,2,4‐triazole‐3‐thiol, 4‐methyl‐1‐substituted‐1 H ‐1,2,4‐triazole‐5(4 H )‐thione 1‐8 were obtained. Molecular structure of the obtained compounds was confirmed by an elemental analysis, IR, 1 H NMR and 13 C NMR spectra and additionally by X‐ray analysis for 2. Six new compounds 1,2,4‐7 were tested for antibacterial activity against Mycobacterium smegmatis, Mycobacterium phlei and avirulent strain Mycobacterium H 37 Ra .