Spontaneous and Induced Variations in Serum Lipoproteins

Abstract

The diurnal variability of several classes of serum lipoproteins and cholesterol has been measured in human subjects. The S f 12-20 class of lipoprotein and the cholesterol were found stable in reference to the technical limitation of the method, but the S f 20-100 class showed significant variation although without evidence of a trend. The effect of intravenous heparin treatment was described. The buccal administration of heparin had no effect. The heparinoid substance Treburon produced a decrease in the S f 20-100 material at three and five hours and decrease in serum total cholesterol and phospholipids at five and seven hours when administered buccally.