The relationship of brevetoxin ‘length’ and A-ring functionality to binding and activity in neuronal sodium channels

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Natural Sciences, Biophysics, Cell Biology +16

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions

S.J. Enna, Solomon H. Snyder · Brain Research · 1975 · 634 citations

Life Sciences, Neurobiology, Neuroscience +14

A rapid method for preparing synaptosomes: Comparison, with alternative procedures

Peter R. Dodd, John Hardy, Arthur E. Oakley et al. · Brain Research · 1981 · 392 citations

Life Sciences, Neuroscience, Cellular Neurobiology +2

Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes.

Mark Poli, Thomas J. Mende, Daniel G. Baden · Molecular Pharmacology · 1986 · 323 citations

Life Sciences, Marine Biology, Neuroscience +15