Concepedia

Toxin-channel Interactions

Toxin-Channel Interactions is a specialized pharmacological phenomenon in which bioactive toxins selectively bind to and modulate the functional states of ion channels, thereby serving as precise molecular probes to elucidate channel structure, function, and therapeutic targeting.

1.7K

Publications

103.6K

Citations

5.1K

Authors

1.1K

Institutions

Publications per year

2017–2026

150

Parents

Publications

1.7K

P-type calcium channels blocked by the spider toxin ω-Aga-IVA

Isabelle M. Mintz, Virginia J. Venema, Kristine M. Swiderek et al. · Nature · 1992 · 879 citations

, , +13

Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle.

Edwin W. McCleskey, A P Fox, Daniel H. Feldman et al. · Proceedings of the National Academy of Sciences · 1987 · 764 citations · Full text

, , +17

Peptide Neurotoxins from Fish-Hunting Cone Snails

Baldomero M. Olivera, William R. Gray, Regina D. Zeikus et al. · Science · 1985 · 748 citations

, , +15

Pharmacological Modifications of the Sodium Channels of Frog Nerve

Bertil Hille · The Journal of General Physiology · 1968 · 488 citations · Full text

, , +17

Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels

Pierre Escoubas, Jan R. de Weille, Alain Lecoq et al. · Journal of Biological Chemistry · 2000 · 472 citations · Full text

, , +17

1–5 of 1.7K

Authors

5.1K

  1. ML
    Michel Lazdunski

    Centre National de la Recherche Scientifique, France

    53 publications · 4.8K citations

    42

    h-index

  2. BM
    Baldomero M. Olivera

    University of Utah, United States

    47 publications · 3.9K citations

    35

    h-index

  3. JT
    Jan Tytgat

    KU Leuven, Belgium

    78 publications · 2.9K citations

    34

    h-index

  4. WA
    William A. Catterall

    University of Washington, United States

    43 publications · 3.7K citations

    33

    h-index

  5. LD
    Lourival D. Possani

    Universidad Nacional Autónoma de México, Mexico

    61 publications · 2.6K citations

    32

    h-index

1–5 of 5.1K

Institutions

1.1K

  1. Centre National de la Recherche Scientifique

    Paris, France

    54 h-index

    642 publications

    38.9K citations

  2. University of Washington

    Seattle, United States

    41 h-index

    162 publications

    13.6K citations

  3. The University of Queensland

    Brisbane, Australia

    39 h-index

    344 publications

    21.1K citations

  4. University of Utah

    Salt Lake City, United States

    38 h-index

    215 publications

    20.6K citations

  5. KU Leuven

    Leuven, Belgium

    35 h-index

    215 publications

    8.4K citations

  6. Universidad Nacional Autónoma de México

    Mexico City, Mexico

    34 h-index

    212 publications

    8.8K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    34 h-index

    79 publications

    9.8K citations

  8. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    33 h-index

    157 publications

    8.3K citations

1–8 of 1.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 211 publications · 16.4K citations

    80

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 80 publications · 9K citations

    58

    h-index

  3. Biochemistry

    125 publications · 7.8K citations

    54

    h-index

  4. FEBS Letters

    74 publications · 4.1K citations

    39

    h-index

  5. Molecular Pharmacology

    58 publications · 3.5K citations

    38

    h-index

1–5