Concepedia

Analysis of physicochemical properties for drugs from nature

B. R. Prashantha Kumar, Mukesh Soni, U. Bharvi Bhikhalal, Ismayil R. Kakkot, Meghana Jagadeesh, Praveen Bommu, M. J. Nanjan

Medicinal Chemistry Research · 2009 · 22 citations · 15 references

Concepts

PharmacyMedicinal ChemistryPharmacologyBioavailabilityDrug DiscoveryStructure-activity RelationshipsDrug DispositionDrug SolubilityMolecular Property PredictionPhysicochemical CharacterizationPhysicochemical Property OptimizationStructure-activity Relationship AnalysisPhysicochemical PropertiesPhysicochemical Property AnalysisPhysicochemical Property Prediction

References

15

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 6.1K citations

Pharmacy, Chemistry, Medicinal Chemistry +14

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

Peter Ertl, Bernhard Rohde, Paul M. Selzer · Journal of Medicinal Chemistry · 2000 · 3K citations

Pharmacy, Chemistry, Pharmacology +15

Simple Selection Criteria for Drug-like Chemical Matter

Ingo Muegge, Sarah L. Heald, David R. Brittelli · Journal of Medicinal Chemistry · 2001 · 1.3K citations

Pharmacy, Medicinal Chemistry, Computational Medicinal Chemistry +11

United States Pharmacopeia

J. H. Gaddum · Nature · 1955 · 903 citations