The Journal of Organic Chemistry · 2006 · 20 citations · 12 references
PharmacyMedicinal ChemistryDrug DiscoveryMacrocycle SynthesisMycotoxinsNatural Toxins In FoodRetrosynthetic AnalysisLactam MacrocyclesLactam SynthesisNatural Product Total SynthesisTethered SynthesisTotal Synthesis-derived Analogues
A concise and efficient total synthesis of the phytotoxin porritoxin is described. The key step of the synthesis is based upon a Parham cyclization methodology which enables the creation of the lactam unit embedded in the title compound framework with the concomitant formation of the tethered hydroxyakyl chain.
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A new approach to isoindoloisoquinolinones. A simple synthesis of nuevamine
Anne Moreau, Axel Couture, Éric Deniau et al. · Tetrahedron · 2004 · 54 citations