Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE2 synthesis

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

Hailing Hsu, David L. Lacey, Colin R. Dunstan et al. · Proceedings of the National Academy of Sciences · 1999 · 1.6K citations

Life Sciences, Cell Biology, Molecular Biology +17

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Jordi Rius, Mónica Gumá, Christian Schachtrup et al. · Nature · 2008 · 1.6K citations · Full text

Life Sciences, Immunology, Molecular Biology +16

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

Zoltàn Arany, ShiYin Foo, Yanhong Ma et al. · Nature · 2008 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Involvement of p38 Mitogen-activated Protein Kinase Signaling Pathway in Osteoclastogenesis Mediated by Receptor Activator of NF-κB Ligand (RANKL)

Masahito Matsumoto, T Sudo, Tamio Saito et al. · Journal of Biological Chemistry · 2000 · 508 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

Eijiro Jimi, Kazuhiro Aoki, Hiroaki Saito et al. · Nature Medicine · 2004 · 501 citations

Medicine, Immunology, Molecular Medicine +16