Azabicyclo[3.1.0]hexane‐1‐carbohydrazides as Potent and Selective GHSR1a Ligands Presenting a Specific in vivo Behavior

Abstract

Buon appetito! The synthesis and in vitro and in vivo profiles of a novel series of potent and selective ghrelin ligands is presented. Selected compounds share the same “atypical” ghrelin antagonist profile already observed with the recently disclosed compound GSK1614343, thus exhibiting the same ability to promote food intake and body weight gain in rodents. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.