Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Manfred Gossen, Heidelberg Bujard · Proceedings of the National Academy of Sciences · 1992 · 4.9K citations

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Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Chunying Du, Min Fang, Yucheng Li et al. · Cell · 2000 · 3.5K citations · Full text

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Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

Reiner U. Jänicke, Michael L. Sprengart, Mas Rina Wati et al. · Journal of Biological Chemistry · 1998 · 1.9K citations · Full text

Endonuclease G is an apoptotic DNase when released from mitochondria

Lily Y. Li, Xu Luo, Xiaodong Wang · Nature · 2001 · 1.7K citations

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A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

Yasuyuki Suzuki, Yuzuru Imai, Hiroshi Nakayama et al. · Molecular Cell · 2001 · 1.1K citations · Full text

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