Concepedia

Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass

Ghislaine Fontès, Bader Zarrouki, Derek Hagman, Martin G. Latour, Meriem Semache, Violet Roskens, Patrick C. Moore, Marc Prentki, Christopher J. Rhodes, Thomas L. Jetton,

Diabetologia · 2010 · 101 citations · 45 references

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45

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed · 1997 · 66.6K citations

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

D. Ross Laybutt, Amanda M. Preston, M. C. Åkerfeldt et al. · Diabetologia · 2007 · 822 citations · Full text

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Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets

R Lupi, Francesco Dotta, Lorella Marselli et al. · Diabetes · 2002 · 602 citations · Full text

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Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death

Wissal El-Assaad, Jean Buteau, Marie‐Line Peyot et al. · Endocrinology · 2003 · 588 citations · Full text

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Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress

Ilham Kharroubi, Laurence Ladrière, Alessandra K. Cardozo et al. · Endocrinology · 2004 · 578 citations

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