Synthetic Communications · 2007 · 12 citations · 26 references
Natural SciencesChemistryGreen ChemistryOrganometallic ChemistrySpectroscopyMicrowave-assisted SynthesisOrganic SynthesisSolvent-free SynthesisAldehydesMicrowave Irradiation EffectsMicrowave-assisted Condensation ReactionsMicrowave-assisted Organic SynthesisMicrowave-assisted Solvent-free Synthesis
Abstract A facile one‐pot method has been developed for the synthesis of fluorine‐containing α‐amino phosphonates in good yields by a three‐component reaction of fluorinated aromatic aldehydes, anilines, and diethyl phosphate in the presence of a silica‐gel support under microwave irradiation within 10 min. All new compounds are fully characterized by spectral methods and elemental analysis. Keywords: α‐aminoalkyl phosphonatesanilinesfluorinated aldehydesmicrowavesolvent free Acknowledgments This work was supported by the National Science Foundation of China (Nos. 20472106, 20532040).
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