Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

Roberto Manetti, Paola Parronchi, M G Giudizi et al. · The Journal of Experimental Medicine · 1993 · 1.7K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

Barry J. Sugarman, Bharat B. Aggarwal, Philip E. Hass et al. · Science · 1985 · 1.6K citations

Medicine, Cancer Biology, Oncology +8

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

Catherine S. Tripp, S F Wolf, Emil R. Unanue · Proceedings of the National Academy of Sciences · 1993 · 781 citations · Full text

Life Sciences, Immunology, Microbiology +17

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

LJ Picker, M. K. Singh, Zoran Z. Zdraveski et al. · Blood · 1995 · 555 citations · Full text

Life Sciences, Cell Biology, Immunology +17

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells

Hans Yssel, René de Waal Malefyt, MG Roncarolo et al. · The Journal of Immunology · 1992 · 410 citations

Life Sciences, Cell Biology, Immunology +14