Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel et al. · Proceedings of the National Academy of Sciences · 1993 · 4.3K citations · Full text

Life Sciences, Genetics, Neurology +17

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

D.T. Vernier · Journal of Lipid Research · 1990 · 3K citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

Yoshio Namba, Masanori Tomonaga, Hiroshi Kawasaki et al. · Brain Research · 1991 · 1.2K citations

Life Sciences, Neurology, Neuroscience +16

The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

Ulrike Beisiegel†, W. Weber, Gudrun Ihrke et al. · Nature · 1989 · 679 citations

Life Sciences, Biochemistry, Molecular Biology +5

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

Maria Z. Kounnas, Robert D. Moir, G. William Rebeck et al. · Cell · 1995 · 495 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10