Presence and Characterization of Prostaglandin D2–Related Molecules in Nasal Mucosa of Patients with Allergic Rhinitis

Abstract

These results suggest that PGD2 is released via the action of h-PGDS from various cells, and the expression of h-PGDS may be associated with the hypertrophic inflammation in the nose. In addition, ligation of PGD2 to CRTH2 appears to be selectively involved in eosinophil recruitment into the nose regardless of atopic status.