Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure

Abstract

A common endothelin-1 gene haplotype may be a pharmacogenetic predictor of a favorable clinical response to beta-blocker therapy in heart failure patients. The existence of a less common 'high-risk' haplotype could identify a subpopulation of heart failure patients destined to respond poorly to beta-blocker therapies.