Critical Care Medicine · 2006 · 2.8K citations · 23 references
This large pan-European study documents the high frequency of sepsis in critically ill patients and shows a close relationship between the proportion of patients with sepsis and the intensive care unit mortality in the various countries. In addition to age, a positive fluid balance was among the strongest prognostic factors for death. Patients with intensive care unit acquired sepsis have a worse outcome despite similar severity scores on intensive care unit admission.
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The Epidemiology of Sepsis in the United States from 1979 through 2000
Greg S. Martin, David M. Mannino, Stephanie Eaton et al. · New England Journal of Medicine · 2003 · 5.8K citations · Full text