Synthesis of 2-(2-adamantyl)piperidines and structure anti-influenza virus a activity relationship study using a combination of NMR spectroscopy and molecular modeling

Influenza virus M2 protein has ion channel activity

Lawrence H. Pinto, Leslie J. Holsinger, Robert A. Lamb · Cell · 1992 · 1.2K citations

Life Sciences, Biology, Molecular Biology +13

The molecular basis of the specific anti‐influenza action of amantadine.

Alan Hay, Adrian J. Wolstenholme, J.J. Skehel et al. · The EMBO Journal · 1985 · 855 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Molecular mechanics calculations on aliphatic amines

S. Profeta, Norman L. Allinger · Journal of the American Chemical Society · 1985 · 180 citations

Natural Sciences, Chemistry, Analytical Chemistry +4

Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans golgi compartment

Fedor Čiampor, Peter M. Bayley, M. V. Nermut et al. · Virology · 1992 · 168 citations

Life Sciences, Microbiology, Molecular Biology +17

Synthesis and Antiviral Activity Evaluation of Some New Aminoadamantane Derivatives. 2

Nicolas Kolocouris, Antonios Kolocouris, George B. Foscolos et al. · Journal of Medicinal Chemistry · 1996 · 155 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16