The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis

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Life Sciences, Genetics, Immunology +12

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

Nunzio Bottini, Lucia Musumeci, Andrés Alonso et al. · Nature Genetics · 2004 · 1.4K citations

Medicine, Biochemistry, Endocrinology +13

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

Torkel Vang, Mauro Congia, Maria Doloretta Macis et al. · Nature Genetics · 2005 · 723 citations

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Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE

Chieko Kyogoku, Ward Ortmann, Annette Lee et al. · The American Journal of Human Genetics · 2004 · 666 citations · Full text

Life Sciences, Genetics, Molecular Genetics +10

Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes

Lindsey A. Criswell, Kirsten A. Pfeiffer, Raymond F. Lum et al. · The American Journal of Human Genetics · 2005 · 600 citations · Full text

Life Sciences, Genetics, Molecular Genetics +15