Science · 1961 · 79 citations · 2 references
Life SciencesInfectious DiseasesMicrobiologyChemotherapyMolecular VirologyVirologyAntiviral AgentsAntiviral Drug ResistanceAntiviral PharmacologyAntiviral ResistanceViral InfectionsViral ReplicationAntiviral Resistance MechanismsAntiviral TherapeuticsCell Culture KineticsDrug Resistance MutationsMolecular Drug ResistanceResistance-associated MutationsViral Replication InhibitionViral Replication Inhibitors
Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.
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Wilton A. Rightsel, J. R. Dice, R. J. McAlpine et al. · Science · 1961 · 123 citations