FEBS Letters · 2000 · 51 citations · 10 references
InflammationNovel Tnf-related MoleculeSignal TransductionSignaling PathwayMurine Tweak LigandMedicineReceptor Tyrosine KinaseApoptosisImmunologyT-regulatory CellCell DeathReceptor (Biochemistry)Death Receptor Wsl‐1/trampWsl-1/tramp Knockout MiceImmunotherapyPharmacologyCell BiologyCell Signaling
WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-kappaB activation and apoptosis. TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL-1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL-1/TRAMP is not the major receptor for TWEAK
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Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95
Arul M. Chinnaiyan, Karen O’Rourke, Guo-Liang Yu et al. · Science · 1996 · 653 citations
A death-domain-containing receptor that mediates apoptosis
Jeremy Kitson, Thomas Raven, Yingping Jiang et al. · Nature · 1996 · 335 citations