Inverse agonism at α2-adrenoceptors in native tissue

The rat brain in stereotaxic coordinates

Miklós Palkovits · Neuropeptides · 1983 · 29K citations

Medicine, Neurobiology, Neuroscience +12

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

Life Sciences, Chemistry, Biomolecular Modeling +11

Interaction of Convulsive Ligands with Benzodiazepine Receptors

Ralph Schmiechen, Günter Neef, Mogens Brøndsted Nielsen et al. · Science · 1982 · 548 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

Tommaso Costa, A. Herz · Proceedings of the National Academy of Sciences · 1989 · 530 citations · Full text

Medicine, Molecular Biology, Pharmacology +15

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

Richard A. Bond, Paul Leff, T. David Johnson et al. · Nature · 1995 · 421 citations

Life Sciences, Pharmacology, Physiology +12