High Frequency of BRAF Mutation in Acquired Nevi and Small Congenital Nevi, but Low Frequency of Mutation in Medium-Sized Congenital Nevi

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

Medicine, Genetics, Molecular Genetics +12

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature · 2005 · 2.1K citations · Full text

Life Sciences, Biology, Cell Biology +12

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

Douglas E. Brash, Jeffrey A. Rudolph, J A Simon et al. · Proceedings of the National Academy of Sciences · 1991 · 2K citations

Medicine, Genetics, Oncology +17

Determinants of BRAF Mutations in Primary Melanomas

Janet L. Maldonado, Jane Fridlyand, Hetal Patel et al. · JNCI Journal of the National Cancer Institute · 2003 · 659 citations · Full text

Medicine, Dermatology, Molecular Genetics +16

Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis.

Roland Houben, Jürgen C. Becker, Andreas Kappel et al. · Journal of Carcinogenesis · 2004 · 283 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +17