Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp21lox mice

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Ruthie E. Amir, Ignatia B. Van den Veyver, Mimi Wan et al. · Nature Genetics · 1999 · 5K citations

Life Sciences, Genetics, Molecular Genetics +9

A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: Report of 35 cases

Bengt Hagberg, Jean Aicardi, Karin Ziliotto Dias et al. · Annals of Neurology · 1983 · 1.5K citations

Medicine, Neurology, Pediatrics +15

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

Richard Z. Chen, Schahram Akbarian, Matthew Tudor et al. · Nature Genetics · 2001 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +14

Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment

Gerd Kempermann, Daniela Gast, Fred H. Gage · Annals of Neurology · 2002 · 893 citations

Medicine, Neurobiology, Neuroscience +17

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Joanna L. Jankowsky, Tatiana Melnikova, Daniel J. Fadale et al. · Journal of Neuroscience · 2005 · 517 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17