Pharmacology · 2008 · 24 citations · 0 references
PharmacyPharmacokineticsPharmacologyBioavailabilityDrug ClearancePharmacokinetic ModelingBioavailability AnalysisDrug DispositionOral BioavailabilityDrug Elimination Half-lifeIntravenous BioavailabilityOpen Compartment SystemsOpen Two-compartment ModelsOral Drug BioavailabilityPharmacokinetic ParametersPharmacokinetics Of Intravenous DrugsVeterinary Pharmacokinetics
A study on galanthamine hydrobromide (Nivalin) pharmacokinetics was carried out on male Wistar rats following single intravenous and oral administration. Plasma samples were collected after decapitation of the animals. The drug concentrations were determined spectrophotofluorometrically. A two-compartment open model was found to describe best the experimental data. Galanthamine has an elimination half-life of 40-50 min, a volume of distribution over 2 liters/kg, a plasma clearance of about 2 liters/h X kg and an oral bioavailability of about 65%.