Concepedia

Open Two-compartment Models

Open Two-Compartment Models is a pharmacokinetic modeling framework that describes the distribution and elimination of substances in a biological system by dividing it into two interconnected compartments with unidirectional or bidirectional transfer, where the system is considered "open" due to irreversible input and/or output of the substance across external boundaries.

359

Publications

14.2K

Citations

1.3K

Authors

361

Institutions

Publications per year

2017–2026

6

Parents

Publications

359

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

K. S. Polonsky, Bruce D. Given, Eve Van Cauter · Journal of Clinical Investigation · 1988 · 762 citations · Full text

, , +13

Pharmacokinetic Parameters in CNS Gd-DTPA Enhanced MR Imaging

Gunnar Brix, Wolfhard Semmler, Rüdiger E. Port et al. · Journal of Computer Assisted Tomography · 1991 · 665 citations

, , +17

Pharmacokinetic Mapping of the Breast: A New Method for Dynamic MR Mammography

Ulf Hoffmann, Gunnar Brix, Michael V. Knopp et al. · Magnetic Resonance in Medicine · 1995 · 308 citations

, , +17

Pharmacokinetics of ceftriaxone in humans

Indravadan H. Patel, S Chen, Mia Parsonnet et al. · Antimicrobial Agents and Chemotherapy · 1981 · 241 citations · Full text

, , +15

Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.

Ulrich Klotz, K. H. Antonin, P. R. Bieck · Journal of Pharmacology and Experimental Therapeutics · 1976 · 212 citations

, , +13

1–5 of 359

Authors

1.3K

  1. AA
    Arturo Anadón

    Universidad Complutense de Madrid, Spain

    7 publications · 437 citations

    7

    h-index

  2. SS
    Samson Symchowicz

    Bloomfield College, United States

    6 publications · 106 citations

    6

    h-index

  3. MR
    María Rosa Martínez-Larrañaga

    Universidad Complutense de Madrid, Spain

    5 publications · 357 citations

    5

    h-index

  4. MC
    Menger Chung

    Pfizer (United States), United States

    5 publications · 85 citations

    5

    h-index

  5. WD
    W. David Wilson

    University of California, Davis, United States

    5 publications · 131 citations

    5

    h-index

1–5 of 1.3K

Institutions

361

  1. Cairo University

    Giza, Egypt

    10 h-index

    13 publications

    256 citations

  2. Universidad Complutense de Madrid

    Madrid, Spain

    7 h-index

    36 publications

    2.7K citations

  3. Virginia–Maryland College of Veterinary Medicine

    Blacksburg, United States

    5 h-index

    13 publications

    466 citations

  4. Auburn University

    Auburn, United States

    5 h-index

    21 publications

    405 citations

  5. University of Michigan

    Ann Arbor, United States

    5 h-index

    11 publications

    388 citations

  6. National Institutes of Health

    Bethesda, United States

    5 h-index

    9 publications

    253 citations

  7. University of California, Davis

    Davis, United States

    5 h-index

    17 publications

    483 citations

  8. Université Paris Cité

    Paris, France

    5 h-index

    27 publications

    1.7K citations

1–8 of 361

Venues

  1. PubMed

    Repository · 81 publications · 2.3K citations

    30

    h-index

  2. Antimicrobial Agents and Chemotherapy

    AAC · 35 publications · 1.9K citations

    22

    h-index

  3. American Journal of Veterinary Research

    AJVR · 26 publications · 1.1K citations

    19

    h-index

  4. Clinical Pharmacology & Therapeutics

    CPT · 20 publications · 716 citations

    17

    h-index

  5. 14

    h-index

1–5