Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity <i>in</i> <i>vivo</i>

Sven Hoffmeyer, Oliver Burk, Oliver von Richter et al. · Proceedings of the National Academy of Sciences · 2000 · 2.4K citations

Medicine, Molecular Genetics, Pharmacology +15

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter Gene<i>ABCB1</i>

Asra Tus Saleha Siddiqui, Reinhold Kerb, Michael E. Weale et al. · New England Journal of Medicine · 2003 · 652 citations · Full text

Medicine, Molecular Genetics, Pharmacology +17

Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin

Sarah K. Tate, Chantal Depondt, Sanjay M. Sisodiya et al. · Proceedings of the National Academy of Sciences · 2005 · 347 citations

Medicine, Pharmacology, Pharmacotherapy +14

Several major antiepileptic drugs are substrates for human P-glycoprotein

Carlos Luna‐Tortós, Maren Fedrowitz, Wolfgang Löscher · Neuropharmacology · 2008 · 308 citations

Medicine, Neurology, Pharmacology +9

The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement

Jan van der Weide, Linda S. W. Steijns, Marga J. M. van Weelden et al. · Pharmacogenetics · 2001 · 198 citations

Medicine, Pharmacokinetics, Pharmacology +15